635292-67-0
Chemical Structure
BC-1175
Synonym(s): CB-181963
- CAS No.: 635292-67-0
- Formula:C19H24FN11O5S2
- Molecular Weight:569.59
IUPAC Name: (6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((fluoromethoxy)imino)acetamido)-3-((E)-(2-(imino(piperazin-1-yl)methyl)-2-methylhydrazono)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: VNZAURNTTOSQRE-XQMVPPGESA-N
SMILES: OC(C1=C(/C=N/N(C)C(N2CCNCC2)=N)CS[C@@]([C@@H]3NC(/C(C4=NSC(N)=N4)=N\OCF)=O)([H])N1C3=O)=O
Biological Activity: BC-1175 (CB-181963) is a novel cephalosporin and antibacterial agent. CB-181963 displays strong binding to altered PBP 2a. CB-181963 demonstrates marked efficacy against MRSA, Klebsiella pneumoniae, Streptococcus pneumoniae, and Escherichia coli[1][2].
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BC-1175 | BC-1175 (CB-181963) is a novel cephalosporin and antibacterial agent. CB-181963 displays strong binding to altered PBP 2a. CB-181963 demonstrates marked efficacy against MRSA, Klebsiella pneumoniae, Streptococcus pneumoniae, and Escherichia coli. | |||||||||||||||||||||
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References
- [1]. Miller K, et al. Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175). J Antimicrob Chemother. 2005 Apr;55(4):579-82. [Content Brief]
- [2]. Huang V, et al. In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci. Antimicrob Agents Chemother. 2004 Jul;48(7):2719-23. [Content Brief]
