635681-64-0
635681-64-0
Chemical Structure
DNA ligase-IN-2
- CAS No.: 635681-64-0
- Formula:C13H8FN3O3
- Molecular Weight:273.22
InChIKey: GCHMLYYPYFXLQB-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N=C1N)OC3=CC=C(F)C=C3C2=O)N
Biological Activity: DNA ligase-IN-2 (compound 2) is a potent LigA inhibitor and inhibits the DNA-independent autoadenylation activity of both full-length LigA and a truncated enzyme, LigA:AD (IC50=29 nM). DNA ligase-IN-2 effectively inhibits the growth of Staphylococcus aureus in vitro, with MIC valuse of 1, 1, and >64 μg/mL for S. aureus ATCC 29213, S. aureus ATCC 700699 and E. coli ATCC 25922, respectively[1].
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DNA ligase-IN-2 | DNA ligase-IN-2 (compound 2) is a potent LigA inhibitor and inhibits the DNA-independent autoadenylation activity of both full-length LigA and a truncated enzyme, LigA:AD (IC50=29 nM). DNA ligase-IN-2 effectively inhibits the growth of Staphylococcus aureus in vitro, with MIC valuse of 1, 1, and >64 μg/mL for S. aureus ATCC 29213, S. aureus ATCC 700699 and E. coli ATCC 25922, respectively. | |||||||||||||||||||||
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