637324-45-9
637324-45-9
Chemical Structure
UCB-6876
- CAS No.: 637324-45-9
- Formula:C17H18N2O
- Molecular Weight:266.34
InChIKey: RZRPPZWEPMDGEI-UHFFFAOYSA-N
SMILES: OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2
Biological Activity: UCB-6876 is a TNFα inhibitor. UCB-6876 specifically binds to the asymmetric crystalline form of TNF-α trimer with a KD of 22 μM. UCB-6876 is applicable to research related to autoimmune diseases (rheumatoid arthritis and Crohn's disease)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UCB-6876 | 98.49% | UCB-6876 is a TNFα inhibitor. UCB-6876 specifically binds to the asymmetric crystalline form of TNF-α trimer with a KD of 22 μM. UCB-6876 is applicable to research related to autoimmune diseases (rheumatoid arthritis and Crohn's disease). | ||||||||||||||||||||
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References
- [1]. O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019;10(1):5795. Published 2019 Dec 19. [Content Brief]
- [2]. Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021;13(1):90. Published 2021 Nov 23. [Content Brief]
