638213-98-6
638213-98-6
Chemical Structure
AGL-2263
- CAS No.: 638213-98-6
- Formula:C17H10N2O5
- Molecular Weight:322.27
IUPAC Name: (E)-2-(3,4-dihydroxybenzoyl)-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)acrylonitrile
InChIKey: IUGRBTCJEYEDIY-VZUCSPMQSA-N
SMILES: O=C(C1=CC(O)=C(O)C=C1)/C(C#N)=C/C2=CC=C(OC3=O)C(N3)=C2
Biological Activity: AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AGL-2263 | 98.31% | AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor. | ||||||||||||||||||||
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Sappanone A | 99.87% | Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular . | ||||||||||||||||||||
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AG 538 | 98.99% | AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM. | ||||||||||||||||||||
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I-OMe-Tyrphostin AG 538 | 98.03% | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM. | ||||||||||||||||||||
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EGFR-IN-16 | EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively. | |||||||||||||||||||||
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Cinnamyl-3,4-dihydroxy-α-cyanocinnamate | 99.41% | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus. | ||||||||||||||||||||
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AG 555 | 98.0% | AG 555 (Tyrphostin AG 555), a potent antiretroviral agent, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation. | ||||||||||||||||||||
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YZL-51N | 95.0% | YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research. | ||||||||||||||||||||
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Butein (Standard) | ≥98% | Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC). | ||||||||||||||||||||
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Z17544625 | Z17544625 is a Fascin inhibitor. Z17544625 has a strong binding capacity to fascin and inhibits Actin bundling. Z17544625 significantly reduces proliferation and impairs migration of CRC cells. Z17544625 can be used for cancer, especially colorectal cancer (CRC) research. | |||||||||||||||||||||
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Tyrphostin AG-808 | Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats. | |||||||||||||||||||||
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References
- [1]. Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705. [Content Brief]
- [2]. Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24(21):2501-8. [Content Brief]
