639089-06-8
639089-06-8
Chemical Structure
VUF 5681 dihydrobromide
- CAS No.: 639089-06-8
- Formula:C11H21Br2N3
- Molecular Weight:355.11
IUPAC Name: 4-(3-(1H-imidazol-5-yl)propyl)piperidine dihydrobromide
InChIKey: YFFVIGXPKWSZHW-UHFFFAOYSA-N
SMILES: C1(CCCC2CCNCC2)=CN=CN1.Br.Br
Biological Activity: VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].
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VUF 5681 dihydrobromide | VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research. | |||||||||||||||||||||
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References
- [1]. Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. [Content Brief]
- [2]. Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9. [Content Brief]
