64022-27-1
Chemical Structure
MK-212
Synonym(s): CPP
- CAS No.: 64022-27-1
- Formula:C8H11ClN4
- Molecular Weight:198.65
IUPAC Name: 2-chloro-6-(piperazin-1-yl)pyrazine
InChIKey: CJAWPFJGFFNXQI-UHFFFAOYSA-N
SMILES: ClC1=NC(N2CCNCC2)=CN=C1
Biological Activity: MK-212 (CPP) is an orally active, blood-brain barrier permeable agonist of 5-HT1C, 5-HT2 and 5-HT1A receptors. MK-212 induces hyperthermia, nausea, arousal, irritability and restlessness, inhibits the elevation of plasma cortisol and prolactin, and reduces feelings of calmness and overall positive affect. MK-212 mediates anxiety-like behaviors and motor inhibition. MK-212 is applicable to research related to schizophrenia and anxiety disorders[1][2].
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MK-212 | MK-212 (CPP) is an orally active, blood-brain barrier permeable agonist of 5-HT1C, 5-HT2 and 5-HT1A receptors. MK-212 induces hyperthermia, nausea, arousal, irritability and restlessness, inhibits the elevation of plasma cortisol and prolactin, and reduces feelings of calmness and overall positive affect. MK-212 mediates anxiety-like behaviors and motor inhibition. MK-212 is applicable to research related to schizophrenia and anxiety disorders. | |||||||||||||||||||||
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References
- [1]. Lee HS, et al. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31(5):460-70. [Content Brief]
- [2]. de Mello Cruz AP, et al. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology. 2005 Nov;182(3):345-54. [Content Brief]
