642-05-7
642-05-7
Chemical Structure
Alloimperatorin
Synonym(s): Prangenidin
- CAS No.: 642-05-7
- Formula:C16H14O4
- Molecular Weight:270.28
IUPAC Name: 9-hydroxy-4-(3-methylbut-2-en-1-yl)-7H-furo[3,2-g]chromen-7-one
InChIKey: KDXVVZMYSLWJMA-UHFFFAOYSA-N
SMILES: C/C(C)=C/CC1=C(C=CO2)C2=C(O)C(O3)=C1C=CC3=O
Biological Activity: Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Alloimperatorin | 99.93% | Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5-Hydroxy-8-methoxypsoralen | 99.82% | 5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Imperatorin | 98.59% | Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Isoimperatorin | 99.78% | Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fipsomin | Fipsomin is a natural product that can be isolated from the fruits of F. nipponica. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Lanatin | Lanatin is a Furanocoumarin. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Phellopterin | 99.94% | Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cnidilin | 99.0% | Cnidilin (Knidilin) is isolated from the root of Angelica dahurica. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
8-Hydroxybergapten | 99.87% | 8-hydroxybergapten is O-methylated by cell-free extracts of Ruta cells to isopimpinellin, in reactions mediated by discrete O-methyltransferases. 8-hydroxybergapten has excellent anti-wrinkle effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Alloisoimperatorin | Alloisoimperatorin (Compound 5) is a phytoestrogen that can be isolated from Angelica dahurica. Alloisoimperatorin can induce alkaline phosphatase (AP) activity with an EC50 of 0.8 μg/mL. Alloisoimperatorin can be used in the study of hormone-dependent cancers and the alleviation of menopausal symptoms. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5,8-Dihydroxypsoralen | 5,8-Dihydroxypsoralen is a natural product. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chen Q, et al. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS. J Sep Sci. 2008 Oct;31(18):3218-24. [Content Brief]
- [2]. Li, H, et al. Alloimperatorin and Its Epoxide Derivative Exhibit in Vitro Antitumor Activity in HL-60 Acute Myeloid Leukemia Cancer Cells via Inducing Apoptosis, Cell Cycle Disruption and Inhibition of Cell Migration. Bangladesh Journal of Pharmacology, Vol. 11, no. 1, Jan. 2016, pp. 194-9.
