64527-08-8
Chemical Structure
Rhamnazin 3-O-rutinoside
Synonym(s): Polygalacin
- CAS No.: 64527-08-8
- Formula:C29H34O16
- Molecular Weight:638.57
InChIKey: JUIYKRQGQJORHH-BDAFLREQSA-N
SMILES: O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)=C(C3=CC(OC)=C(C=C3)O)OC4=CC(OC)=C5)C4=C5O
Biological Activity: Rhamnazin 3-O-rutinoside (Polygalacin) is a flavonoid compound. Rhamnazin 3-O-rutinoside can be extracted from Areca catechu L. Rhamnazin 3-O-rutinoside shows no significant inhibitory effect on recombinant hPTP1B, with an IC50 > 100 μM. Rhamnazin 3-O-rutinoside reduces Apoptotic cell death. Rhamnazin 3-O-rutinoside possesses cellular antioxidant activity and alleviates H2O2-induced oxidative stress. Rhamnazin 3-O-rutinoside lacks free radical scavenging activity. Rhamnazin 3-O-rutinoside can be used in the research of neurodegenerative diseases[1][2][3].
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Rhamnazin 3-O-rutinoside | Rhamnazin 3-O-rutinoside (Polygalacin) is a flavonoid compound. Rhamnazin 3-O-rutinoside can be extracted from Areca catechu L. Rhamnazin 3-O-rutinoside shows no significant inhibitory effect on recombinant hPTP1B, with an IC50 > 100 μM. Rhamnazin 3-O-rutinoside reduces Apoptotic cell death. Rhamnazin 3-O-rutinoside possesses cellular antioxidant activity and alleviates H2O2-induced oxidative stress. Rhamnazin 3-O-rutinoside lacks free radical scavenging activity. Rhamnazin 3-O-rutinoside can be used in the research of neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Ha M T, et al. A New Methoxyflavonoid Rutinoside and PTP1B-Inhibitory Phenolic Compounds from the Water Extract of Areca catechu L[J]. Natural Product Sciences, 2026, 32(1): 50-55.
- [2]. Wang W, et al. Isolation and purification of flavonoids from Euonymus alatus by high-speed countercurrent chromatography and neuroprotective effect of rhamnazin-3-O-rutinoside in vitro. Journal of separation science. 2021 Dec;44(24):4422-4430. [Content Brief]
- [3]. HARPUT Ü Ş, et al. Methoxyflavonoids from Pinaropappus roseus[J]. Turkish Journal of Chemistry, 2004, 28(6): 761-766.
