648895-38-9
648895-38-9
Chemical Structure
Bapineuzumab
Synonym(s): AAB-001
- CAS No.: 648895-38-9
- Formula:N/A
- Molecular Weight:(144.5 kDa)
IUPAC Name: tert-butyl (5-iodopyrimidin-2-yl)carbamate
SMILES: [Bapineuzumab]
Biological Activity: Bapineuzumab (AAB-001) is a humanized IgG1 monoclonal antibody that binds to the N-terminal region of amyloid beta in a helical conformation. Bapineuzumab induces microglial activation by upregulating CD11B, producing pro-inflammatory cytokines (IL-1β and TNFα), clearing plaques, and reducing insoluble and aggregated Aβ. Bapineuzumab can be used for research on Alzheimer's disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bapineuzumab | 99.00% | Bapineuzumab (AAB-001) is a humanized IgG1 monoclonal antibody that binds to the N-terminal region of amyloid beta in a helical conformation. Bapineuzumab induces microglial activation by upregulating CD11B, producing pro-inflammatory cytokines (IL-1β and TNFα), clearing plaques, and reducing insoluble and aggregated Aβ. Bapineuzumab can be used for research on Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Fuller JP, et al. Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies. Acta neuropathologica. 2015 Nov;130(5):699-711. [Content Brief]
- [2]. Lope-Piedrafita S, et al. ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer's Disease. Biomolecules. 2025 Nov 15;15(11):1602.
- [3]. Salloway S, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. The New England journal of medicine. 2014 Jan 23;370(4):322-33. [Content Brief]
- [4]. Bouter Y, et al. Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models. Acta neuropathologica. 2015 Nov;130(5):713-29.
