64936-82-9
Chemical Structure
Glycolithocholic acid 3-sulfate disodium
Synonym(s): Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodium
- CAS No.: 64936-82-9
- Formula:C26H41NNa2O7S
- Molecular Weight:557.65
IUPAC Name: sodium ((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(sulfonatooxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycinate
InChIKey: FXMCQRUEVPOMSC-DJOVSRRHSA-L
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)(O[Na])=O)([H])CC3)C
Biological Activity: Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glycolithocholic acid 3-sulfate disodium | 99.99% | Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease. | ||||||||||||||||||||
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Glycolithocholic acid 3-sulfate-d4 disodium | 99.60% | Glycolithocholic acid 3-sulfate-d4 disodium is the deuterium labeled Glycolithocholic acid 3-sulfate (HY-113074). | ||||||||||||||||||||
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References
- [1]. Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988). 1989;2(3):264-271. [Content Brief]
- [2]. I M Yousef, et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80(2):233-41. [Content Brief]
- [3]. Zi, Zhentao; Xian, Yi; Han, Shangchen; Zhou, Enxing; Wang, Meihuang; Rao, Yi. Use of bile acids and derivatives thereof in preparation of GPR39 agonist. WO2021083336A1.
