6500-81-8
Chemical Structure
Ethacrynic acid sodium
Synonym(s): Etacrynic acid sodium; Sodium etacrynate
- CAS No.: 6500-81-8
- Formula:C13H11Cl2NaO4
- Molecular Weight:325.12
IUPAC Name: sodium 2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetate
InChIKey: CWCSCNSKBSCYCS-UHFFFAOYSA-M
SMILES: O=C(O[Na])COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl
Biological Activity: Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
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Ethacrynic acid sodium | Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice. | |||||||||||||||||||||
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