65025-62-9
65025-62-9
Chemical Structure
Soulattrolide
- CAS No.: 65025-62-9
- Formula:C25H24O5
- Molecular Weight:404.46
InChIKey: BXENDTPSKAICGV-RXSFTSLZSA-N
SMILES: O[C@@H]1C2=C(O[C@H]([C@@H]1C)C)C(C=CC(C)(O3)C)=C3C(C(C4=CC=CC=C4)=C5)=C2OC5=O
Biological Activity: Soulattrolide is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor with IC50 values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human DNA polymerase β, and can be found in Calophyllum teysmannii latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection[1][2].
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Soulattrolide | Soulattrolide is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor with IC50 values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human DNA polymerase β, and can be found in Calophyllum teysmannii latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection. | |||||||||||||||||||||
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References
- [1]. Pengsuparp T, et al. Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii. J Nat Prod. 1996;59(9):839-842. [Content Brief]
- [2]. Alonso-Castro AJ, et al. Antinociceptive, anti-inflammatory, and central nervous system (CNS) effects of the natural coumarin soulattrolide. Drug Dev Res. 2018;79(7):332-338. [Content Brief]
