651029-09-3
651029-09-3
Chemical Structure
KCL-440
- CAS No.: 651029-09-3
- Formula:C18H18N2O2
- Molecular Weight:294.35
IUPAC Name: 4-(4-((dimethylamino)methyl)phenyl)-5-hydroxyisoquinolin-1(2H)-one
InChIKey: NCBXZVLOVKDCMW-UHFFFAOYSA-N
SMILES: O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31
Biological Activity: KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1[1][2].
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KCL-440 | KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1. | |||||||||||||||||||||
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References
- [1]. Yasuhiko Ikeda, et al. Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. Brain Res. 2005 Oct 26;1060(1-2):73-80. [Content Brief]
- [2]. Tatsushi Kamiya, et al. The neuroprotective effects of a newly synthesized poly (ADP-ribose) polymerase (PARP) inhibitor (KCL-440) on neuronal cell death following transient focal ischemia in rat. Journal of Cerebral Blood Flow & Metabolism. 2005.
