65199-10-2
65199-10-2
Chemical Structure
Nitrobenzylthioinosine 5'-monophosphate
Synonym(s): NBMPR-P
- CAS No.: 65199-10-2
- Formula:C17H18N5O9PS
- Molecular Weight:499.39
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N(C=N2)C3=C2C(SCC4=CC=C([N+]([O-])=O)C=C4)=NC=N3
Biological Activity: Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126)[1][2].
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Nitrobenzylthioinosine 5'-monophosphate | Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126). | |||||||||||||||||||||
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References
- [1]. Patel DH, et al. Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells. Blood. 2000 Apr 1;95(7):2356-63. [Content Brief]
- [2]. el Kouni MH, et al. Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6667-70. [Content Brief]
