65281-77-8
Chemical Structure
12,14-Dichlorodehydroabietic acid
- CAS No.: 65281-77-8
- Formula:C20H26Cl2O2
- Molecular Weight:369.33
IUPAC Name: (1R,4aS,10aR)-6,8-dichloro-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
InChIKey: RKQWIQSTFSBVMQ-CDHQVMDDSA-N
SMILES: O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O
Biological Activity: 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].
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12,14-Dichlorodehydroabietic acid | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release. | |||||||||||||||||||||
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References
- [1]. R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32. [Content Brief]
- [2]. Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53. [Content Brief]
