65678-07-1
65678-07-1
Chemical Structure
AG1024
Synonym(s): Tyrphostin AG 1024
- CAS No.: 65678-07-1
- Formula:C14H13BrN2O
- Molecular Weight:305.17
IUPAC Name: 2-(3-bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile
InChIKey: ABBADGFSRBWENF-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1
Biological Activity: AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[1][2].
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AG1024 | 99.50% | AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity. | ||||||||||||||||||||
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AG1024 (Standard) | ≥98% | AG1024 (Standard) is the analytical standard of AG1024 (HY-10253). This product is intended for research and analytical applications. AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity. | ||||||||||||||||||||
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References
- [1]. Párrizas M, et al. Specific inhibition of IGF-1R and IR tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33. [Content Brief]
- [2]. Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91(9):1735-41. [Content Brief]
