65886-80-8
Chemical Structure
18:0-22:6 DG
Synonym(s): 1-Stearoyl-2-docosahexaenoyl-sn-glycerol
- CAS No.: 65886-80-8
- Formula:C43H72O5
- Molecular Weight:669.03
IUPAC Name: (E)-N-hydroxy-3-(1-((4-methoxyphenyl)sulfonyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)acrylamide
InChIKey: LBDXVTOFXXDOGH-KXYFHQNYSA-N
SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O[C@@H](CO)COC(CCCCCCCCCCCCCCCCC)=O)=O
Biological Activity: 18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (Ki = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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18:0-22:6 DG | 99% | 18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (Ki = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease. | ||||||||||||||||||||
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References
- [1]. Madani S, et, al. Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem. 2004 Jan 9;279(2):1176-83. [Content Brief]
- [2]. Kamiya Y, et al. Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species. Biochem Biophys Rep. 2016 Jul 20;7:361-366. [Content Brief]
