659731-59-6
659731-59-6
Chemical Structure
AMG8163
- CAS No.: 659731-59-6
- Formula:C25H22F3N5O4S
- Molecular Weight:545.53
IUPAC Name: tert-butyl (2-(6-((2-acetamidobenzo[d]thiazol-4-yl)oxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)carbamate
InChIKey: JXKLZZJMXYNAFG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)(F)F)=CC=C1C2=NC=NC(OC3=C4N=C(SC4=CC=C3)NC(C)=O)=C2)OC(C)(C)C
Biological Activity: AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448)-induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models[1].
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AMG8163 | AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448)-induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models. | |||||||||||||||||||||
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