65988-34-3
Chemical Structure
α-Latrotoxin
Synonym(s): α-LTX
- CAS No.: 65988-34-3
- Formula:N/A
- Molecular Weight:N/A
SMILES: [a-Latrotoxin]
Biological Activity: α‑Latrotoxin (α-LTX) is a neurotoxin found in the genus Latrodectus. α-Latrotoxin binds to presynaptic receptors such as neurexin and latrophilin-1, inserts into the cell membrane to form non-selective cation channels, and induces massive exocytosis of neurotransmitters and hormones through dual mechanisms of receptor dependence and pore formation, triggering calcium signaling disturbances and electrophysiological alterations. α-Latrotoxin can be used in research related to synaptic vesicle exocytosis and neurotransmitter release[1][2][3][4][5][6].
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α-Latrotoxin | α‑Latrotoxin (α-LTX) is a neurotoxin found in the genus Latrodectus. α-Latrotoxin binds to presynaptic receptors such as neurexin and latrophilin-1, inserts into the cell membrane to form non-selective cation channels, and induces massive exocytosis of neurotransmitters and hormones through dual mechanisms of receptor dependence and pore formation, triggering calcium signaling disturbances and electrophysiological alterations. α-Latrotoxin can be used in research related to synaptic vesicle exocytosis and neurotransmitter release. | |||||||||||||||||||||
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References
- [1]. Südhof TC, et al. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annual review of neuroscience. 2001;24:933-62. [Content Brief]
- [2]. Graudins A, et al. Red-back spider (Latrodectus hasselti) antivenom prevents the toxicity of widow spider venoms. Annals of emergency medicine. 2001 Feb;37(2):154-60.
- [3]. Davletov B, et al. α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism. Toxins. 2026 Sep 10;18(9):393.
- [4]. Krasnoperov VG, et al. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron. 1997 Jun;18(6):925-37.
- [5]. Graudins A, et al. Cloning and activity of a novel α-latrotoxin from red-back spider venom. Biochemical pharmacology. 2012 Jan 1;83(1):170-83.
- [6]. Graudins A, et al. Cloning and activity of a novel α-latrotoxin from red-back spider venom. Biochemical pharmacology. 2012 Jan 01;83(1):170-83.
