66508-53-0
66508-53-0
Chemical Structure
Fosmidomycin
- CAS No.: 66508-53-0
- Formula:C4H10NO5P
- Molecular Weight:183.10
IUPAC Name: (3-(N-hydroxyformamido)propyl)phosphonic acid
InChIKey: GJXWDTUCERCKIX-UHFFFAOYSA-N
SMILES: OP(O)(CCCN(C=O)O)=O
Biological Activity: Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model[1].
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Fosmidomycin | Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model. | |||||||||||||||||||||
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