66592-89-0
66592-89-0
Chemical Structure
Kevetrin hydrochloride
Synonym(s): 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride
- CAS No.: 66592-89-0
- Formula:C5H10ClN3S
- Molecular Weight:179.67
IUPAC Name: 3-cyanopropyl carbamimidothioate hydrochloride
InChIKey: NCXJZJFDQMKRKM-UHFFFAOYSA-N
SMILES: NC(SCCCC#N)=N.[H]Cl
Biological Activity: Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kevetrin hydrochloride | 98.0% | Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells. | ||||||||||||||||||||
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Kevetrin-13C2,15N3 hydrochloride | Kevetrin (hydrochloride)-13C2,15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. | |||||||||||||||||||||
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References
- [1]. Napolitano R, et al. Kevetrin induces apoptosis in TP53 wildtype and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Oct;44(4):1561-1573. [Content Brief]
- [2]. Kumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independKumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies. Cancer Research. 2017. 77(13 Supplement), 3221-3221.
