669750-88-3
669750-88-3
Chemical Structure
AKCI
- CAS No.: 669750-88-3
- Formula:C19H27N7O
- Molecular Weight:369.46
IUPAC Name: 4,8-dimethyl-N-(5-(2-morpholinoethyl)-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl)quinazolin-2-amine
InChIKey: ZUHMBCQGKZNQCK-UHFFFAOYSA-N
SMILES: CC1=CC=CC2=C(N=C(N=C12)NC3=NCN(CCN4CCOCC4)CN3)C
Biological Activity:
AKCI is a type of AURKC-IκBα interaction inhibitor, with an IC50 value of 24.9 μM. In MDA-MB-231 cells, AKCI can induce G2/M cell cycle arrest by regulating the p53/p21/CDC2/cyclin B1 pathway, inhibit cell migration and invasion, and reduce colony formation and tumor growth. AKCI can be used for research on breast cancer[1].
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AKCI | AKCI is a type of AURKC-IκBα interaction inhibitor, with an IC50 value of 24.9 μM. In MDA-MB-231 cells, AKCI can induce G2/M cell cycle arrest by regulating the p53/p21/CDC2/cyclin B1 pathway, inhibit cell migration and invasion, and reduce colony formation and tumor growth. AKCI can be used for research on breast cancer. |
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