670225-69-1
Chemical Structure
Aspochalasin I
- CAS No.: 670225-69-1
- Formula:C24H35NO5
- Molecular Weight:417.54
IUPAC Name: (3S,3aS,4S,6aS,7E,11S,12R,13E,16aR)-11,12-dihydroxy-3-isobutyl-4,5,8-trimethyl-3,3a,4,6a,9,10,11,12-octahydro-1H-[1]oxacyclododecino[2,3-d]isoindole-1,15(2H)-dione
InChIKey: TYOGSRFPSVCJQL-QYNSZGEFSA-N
SMILES: CC1=C[C@@](/C=C(C)/CC[C@H](O)[C@H](O)/C=C/2)([H])[C@@]3(OC2=O)[C@@]([C@H](CC(C)C)NC3=O)([H])[C@@H]1C
Biological Activity: Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent[1][2].
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Aspochalasin I | Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent. | |||||||||||||||||||||
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References
- [1]. Choo SJ, et al., Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp. J Microbiol Biotechnol. 2009 Apr;19(4):368-71 [Content Brief]
- [2]. Zhou GX, et al., Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32. [Content Brief]
