67076-74-8
67076-74-8
Chemical Structure
Globomycin
- CAS No.: 67076-74-8
- Formula:C32H57N5O9
- Molecular Weight:655.82
InChIKey: VFGBXFZXJAWPOE-PEOIOWGVSA-N
SMILES: CC(C)C[C@@](N(C([C@@H]([C@H](OC(CNC1=O)=O)CCCCCC)C)=O)C)([H])C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@@H](O)C)=O)CO)=O)([H])[C@H](C)CC)=O
Biological Activity: Globomycin is a lipopeptide antibiotic and a signal peptidase II (LspA) inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute Spiroplasma melliferum with a MIC in the range 6.25-12.5 μM[1][2].
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Globomycin | Globomycin is a lipopeptide antibiotic and a signal peptidase II (LspA) inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute Spiroplasma melliferum with a MIC in the range 6.25-12.5 μM. | |||||||||||||||||||||
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References
- [1]. Béven L, et al. Inhibition of spiralin processing by the lipopeptide antibiotic globomycin. Curr Microbiol. 1996 Nov;33(5):317-22. [Content Brief]
- [2]. Parthasarathy S, et al. Organophosphate Hydrolase Is a Lipoprotein and Interacts with Pi-specific Transport System to Facilitate Growth of Brevundimonas diminuta Using OP Insecticide as Source of Phosphate. J Biol Chem. 2016 Apr 1;291(14):7774-85. [Content Brief]
