67287-49-4
67287-49-4
Chemical Structure
SKF 38393
- CAS No.: 67287-49-4
- Formula:C16H17NO2
- Molecular Weight:255.31
IUPAC Name: 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
InChIKey: JUDKOGFHZYMDMF-UHFFFAOYSA-N
SMILES: OC1=C(O)C=C(C(CNCC2)C3=CC=CC=C3)C2=C1
Biological Activity: SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM). SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers[1][2].
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SKF 38393 | SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM). SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers. | |||||||||||||||||||||
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References
- [1]. Walters DE, et al. The D1 agonist SKF 38393 increases dopamine release in the developing rat striatum. Eur J Pharmacol. 1990 Aug 10;184(2-3):257-64. [Content Brief]
- [2]. Johnson DE, et al. The growth inhibitory properties of a dopamine agonist (SKF 38393) on MCF-7 cells. Anticancer Drugs. 1995 Jun;6(3):471-4. [Content Brief]
