67494-15-9
Chemical Structure
Pisiferic acid
- CAS No.: 67494-15-9
- Formula:C20H28O3
- Molecular Weight:316.43
IUPAC Name: 2-phenylbenzo[d]oxazole-6-carbaldehyde
InChIKey: ATHWSPHADLLZSS-PXNSSMCTSA-N
SMILES: O=C([C@]12CCCC(C)(C)[C@]1([H])CCC3=C2C=C(O)C(C(C)C)=C3)O
Biological Activity: Pisiferic acid is a blood-brain barrier-permeable Kv1.1/Kv1.2 opener and Antibacterial agent. Pisiferic acid has no activity against KCNQ2/3, hERG, or Kv2.1. Pisiferic acid inhibits Perilipin1 and PPARγ protein expression. Pisiferic acid activates PP2C, inhibits PP2B/calcineurin, and induces Apoptosis/Caspase-3/7. Pisiferic acid inhibits macromolecule synthesis in Proteus vulgaris and inhibits DNA/lipid/peptidoglycan synthesis in Bacillus subtilis. Pisiferic acid has antibacterial effects against Proteus vulgaris, Staphylococcus aureus, and Bacillus subtilis. Pisiferic acid can be used for research on episodic ataxia type 1, Kv1.2 loss-of-function channelopathy, obesity, and acute promyelocytic leukemia[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pisiferic acid | 99.44% | Pisiferic acid is a blood-brain barrier-permeable Kv1.1/Kv1.2 opener and Antibacterial agent. Pisiferic acid has no activity against KCNQ2/3, hERG, or Kv2.1. Pisiferic acid inhibits Perilipin1 and PPARγ protein expression. Pisiferic acid activates PP2C, inhibits PP2B/calcineurin, and induces Apoptosis/Caspase-3/7. Pisiferic acid inhibits macromolecule synthesis in Proteus vulgaris and inhibits DNA/lipid/peptidoglycan synthesis in Bacillus subtilis. Pisiferic acid has antibacterial effects against Proteus vulgaris, Staphylococcus aureus, and Bacillus subtilis. Pisiferic acid can be used for research on episodic ataxia type 1, Kv1.2 loss-of-function channelopathy, obesity, and acute promyelocytic leukemia. | ||||||||||||||||||||
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References
- [1]. Manville RW, et al. Rosemary metabolite carnosic acid opens K1.1 via its voltage sensor and corrects K1.1-linked episodic ataxia in mice. British journal of pharmacology. 2026 Oct;183(20):6179-6198.
- [2]. Manville RW, et al. Conifer metabolite pisiferic acid restores activity in human Kv1.2 potassium channels carrying pathogenic sequence variants. iScience. 2025 Sep 19;28(9):113283.
- [3]. Oshika A, et al. Synthesis of pisiferic acid analogues and their anti-adipogenic effect in 3T3-L1 adipocytes. Bioorganic & Medicinal Chemistry Letters. 2025 Aug 5:130354.
- [4]. Aburai N, et al. Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Aug;17(10):782-8.
- [5]. Koji Kobayashi, et al. Antibacterial Activity of Pisiferic Acid and Its Derivatives against Gram-negative and -positive Bacteria. Agric Biol Chem. 1988 Jan 1;52(1): 77-83.
