675126-26-8
Chemical Structure
Gefitinib impurity 1
- CAS No.: 675126-26-8
- Formula:C15H19N3O5
- Molecular Weight:321.33
IUPAC Name: 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
InChIKey: FYCDMKYKGPHRFW-UHFFFAOYSA-N
SMILES: N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O
Biological Activity: Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
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Gefitinib impurity 1 | 99.59% | Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity. | ||||||||||||||||||||
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Gefitinib impurity 1 (Standard) | ≥98% | Gefitinib impurity 1 (Standard) is the analytical standard of Gefitinib impurity 1 (HY-131257). This product is intended for research and analytical applications. Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity. | ||||||||||||||||||||
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