67667-71-4
Chemical Structure
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate
- CAS No.: 67667-71-4
- Formula:C21H26O8
- Molecular Weight:406.43
IUPAC Name: (4S,6R,7S,10R,E)-3-(acetoxymethyl)-7-hydroxy-6,10-dimethyl-2-oxo-2,4,5,6,7,8,9,10-octahydro-7,10-epoxycyclodeca[b]furan-4-yl methacrylate
InChIKey: YKIDGUZXBGGNBZ-GUNZAYKBSA-N
SMILES: CC(OCC1=C([C@H](C[C@H]2C)OC(C(C)=C)=O)/C(OC1=O)=C\[C@](O[C@]23O)(CC3)C)=O
Biological Activity: 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].
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8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively. | |||||||||||||||||||||
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