6779-87-9
Chemical Structure
7,8-Dihydro-L-biopterin
Synonym(s): Dihydrobiopterin
- CAS No.: 6779-87-9
- Formula:C9H13N5O3
- Molecular Weight:239.23
IUPAC Name: 2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydropteridin-4(1H)-one
InChIKey: FEMXZDUTFRTWPE-DZSWIPIPSA-N
SMILES: O=C1N=C(N)NC2=C1N=C([C@@H](O)[C@@H](O)C)CN2
Biological Activity: 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases[1][2][3][4].
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7,8-Dihydro-L-biopterin | 99.79% | 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases. | ||||||||||||||||||||
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7,8-Dihydro-L-biopterin (Standard) | 96.47% | 7,8-Dihydro-L-biopterin (Standard) (Dihydrobiopterin (Standard)) is the analytical standard of 7,8-Dihydro-L-biopterin (HY-W008646). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Taylor N E, et al. NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterin[J]. Hypertension, 2006, 48(6): 1066-1071.
- [2]. Stover J F, et al. Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA)[J]. Journal of neurotrauma, 2014, 31(19): 1599-1606.
- [3]. Espinosa-Mansilla A, et al. LC determination of biopterin reduced forms by UV-photogeneration of biopterin and fluorimetric detection[J]. Talanta, 2008, 77(2): 844-851.
- [4]. Enzinger C, et al. Reduced pteridine derivatives induce apoptosis in PC12 cells. Neurochem Int. 2002;41(1):71-78. [Content Brief]
