678967-50-5
Chemical Structure
Pac-525
- CAS No.: 678967-50-5
- Formula:C68H100N22O10
- Molecular Weight:1385.66
InChIKey: YPQQTVCSKDHPKX-NMXMAWPBSA-N
SMILES: O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: Pac-525 is a tryptophan-rich cationic antibacterial peptide and membrane-disrupting agent. Pac-525 exhibits antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, *Candida albicans* and *Fusarium solani*. Pac-525 interacts strongly with negatively charged phospholipid vesicles, induces vesicle dye release and disrupts microbial membranes. Pac-525 shows cytotoxicity against macrophages. Pac-525 can be used in studies related to bacterial and fungal infections[1][2].
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Pac-525 | Pac-525 is a tryptophan-rich cationic antibacterial peptide and membrane-disrupting agent. Pac-525 exhibits antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, *Candida albicans* and *Fusarium solani*. Pac-525 interacts strongly with negatively charged phospholipid vesicles, induces vesicle dye release and disrupts microbial membranes. Pac-525 shows cytotoxicity against macrophages. Pac-525 can be used in studies related to bacterial and fungal infections. | |||||||||||||||||||||
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References
- [1]. Coufalova M, et al. Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli. Scientific reports. 2025 Jun 06;15(1):19995. [Content Brief]
- [2]. Wei SY, et al. Solution structure of a novel tryptophan-rich peptide with bidirectional antimicrobial activity. Journal of bacteriology. 2006 Jan;188(1):328-34. [Content Brief]
