67914-61-8
67914-61-8
Chemical Structure
Deacylketoconazole
Synonym(s): N-Deacetylketoconazole; R-39519
- CAS No.: 67914-61-8
- Formula:C24H26Cl2N4O3
- Molecular Weight:489.39
IUPAC Name: 1-(4-(((2S,4R)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
InChIKey: LOUXSEJZCPKWAX-ZJSXRUAMSA-N
SMILES: ClC1=CC=C(C(Cl)=C1)[C@@]2(OC[C@H](O2)COC3=CC=C(C=C3)N4CCNCC4)CN5C=CN=C5
Biological Activity: Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Deacylketoconazole | 99.60% | Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte. | ||||||||||||||||||||
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References
- [1]. Pfaller MA, et al., Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates. Antimicrob Agents Chemother. 1982 Nov;22(5):917-9. [Content Brief]
- [2]. Bossche H V, et al., Molecular basis for the antimycotic and antibacterial activity of N‐substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesis[J]. Pesticide science, 1984, 15(2): 188-198.
- [3]. Fukami T, et al., Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016 Sep 15;116:153-61. [Content Brief]
