68054-78-4
Chemical Structure
CPPD-Q
- CAS No.: 68054-78-4
- Formula:C18H20N2O2
- Molecular Weight:296.36
InChIKey: UBQBKNFAICQJRN-UHFFFAOYSA-N
SMILES: O=C1C(NC2CCCCC2)=CC(C(NC3=CC=CC=C3)=C1)=O
Biological Activity: CPPD-Q is a PPD-quinone. CPPD-Q induces increased intestinal permeability and oxidative stress in C. elegans. CPPD-Q targets HMP-2 and ACS-22 to regulate the intestinal barrier, and targets SOD-3 and GST-4 to mediate oxidative stress responses. CPPD-Q induces reactive oxygen species (ROS) production through quinone-mediated redox cycling, and exhibits oxidative potential through dithiothreitol depletion. CPPD-Q is used in research related to intestinal diseases[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CPPD-Q | 99.12% | CPPD-Q is a PPD-quinone. CPPD-Q induces increased intestinal permeability and oxidative stress in C. elegans. CPPD-Q targets HMP-2 and ACS-22 to regulate the intestinal barrier, and targets SOD-3 and GST-4 to mediate oxidative stress responses. CPPD-Q induces reactive oxygen species (ROS) production through quinone-mediated redox cycling, and exhibits oxidative potential through dithiothreitol depletion. CPPD-Q is used in research related to intestinal diseases. | ||||||||||||||||||||
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References
- [1]. Wang Y, et al. Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans. The Science of the total environment. 2024 Jun 01;927:172306. [Content Brief]
- [2]. Zhang S, et al. Trans-Placental Transfer Mechanisms of Aromatic Amine Antioxidants (AAs) and -Phenylenediamine Quinones (PPD-Qs): Evidence from Human Gestation Exposure and the Rat Uterine Perfusion Model. Environmental science & technology. 2024 Dec 03;58(48):21166-21176.
- [3]. Zhang S, et al. Oxidative damage induced by daily exposure to primary and emerging aromatic amines: Insights from large scale biomonitoring and cell-based high-throughput PCR array analysis. Journal of hazardous materials. 2025 Sep 15;496:139300.
- [4]. Nair P, et al. Synthesis and Toxicity Evaluation of -Phenylenediamine-Quinones. Environmental science & technology. 2025 Apr 22;59(15):7485-7494.
- [5]. Wang W, et al. Toxicity of substituted p-phenylenediamine antioxidants and their derived novel quinones on aquatic bacterium: Acute effects and mechanistic insights. Journal of hazardous materials. 2024 May 05;469:133900. [Content Brief]
- [6]. Xia K, et al. Elucidating the size distribution of p‑Phenylenediamine-Derived quinones in atmospheric particles. Environment international. 2025 Mar;197:109329.
- [7]. Wang W, et al. p-Phenylenediamine-derived quinones as new contributors to the oxidative potential of fine particulate matter. Environmental Science & Technology Letters. 2022 Aug 10;9(9):712-7.
