681293-15-2
681293-15-2
Chemical Structure
δ-Viniferin
- CAS No.: 681293-15-2
- Formula:C28H22O6
- Molecular Weight:454.47
InChIKey: LILPTCHQLRKZNG-LPGNHZEISA-N
SMILES: OC1=CC(O)=CC(/C=C/C2=CC=C3O[C@H](C4=CC=C(C=C4)O)[C@@H](C5=CC(O)=CC(O)=C5)C3=C2)=C1
Biological Activity: δ-Viniferin is a COX-1/COX-2 inhibitor (with an IC50 of 5 µM for both enzymes). δ-Viniferin induces the expression of SIRT1, catalase and HO-1, promotes the phosphorylation of eNOS, and stimulates nitric oxide (NO) production. δ-Viniferin is applicable to research related to atherosclerosis, downy mildew, Gram-positive bacterial infections, inflammation, infections, cardiovascular diseases and diabetes[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
δ-Viniferin | δ-Viniferin is a COX-1/COX-2 inhibitor (with an IC50 of 5 µM for both enzymes). δ-Viniferin induces the expression of SIRT1, catalase and HO-1, promotes the phosphorylation of eNOS, and stimulates nitric oxide (NO) production. δ-Viniferin is applicable to research related to atherosclerosis, downy mildew, Gram-positive bacterial infections, inflammation, infections, cardiovascular diseases and diabetes. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Wu CW, et al. Resveratrol and its dimers ε-viniferin and δ-viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy. The Kaohsiung journal of medical sciences. 2020 Jul;36(7):535-542.
- [2]. Pezet R, et al. Delta-viniferin, a resveratrol dehydrodimer: one of the major stilbenes synthesized by stressed grapevine leaves. Journal of agricultural and food chemistry. 2003 Aug 27;51(18):5488-92. [Content Brief]
- [3]. Vitrac X, et al. Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines. Journal of agricultural and food chemistry. 2005 Jul 13;53(14):5664-9.
- [4]. Mattio LM, et al. Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres. Molecules (Basel, Switzerland). 2021 Dec 15;26(24):7594.
- [5]. Mao P, et al. Pharmacokinetics, bioavailability, metabolism and excretion of δ-viniferin in rats. Acta pharmaceutica Sinica. B. 2016 May;6(3):243-52.
