68206-94-0
Chemical Structure
Cloricromen
Synonym(s): Cloricromene; AD6
- CAS No.: 68206-94-0
- Formula:C20H26ClNO5
- Molecular Weight:395.88
IUPAC Name: ethyl 2-((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetate
InChIKey: GYNNRVJJLAVVTQ-UHFFFAOYSA-N
SMILES: O=C(COC1=CC=C(C(C)=C2CCN(CC)CC)C(OC2=O)=C1Cl)OCC
Biological Activity: Cloricromen (Cloricromene) is an orally active platelet inhibitor. Cloricromen inhibits thromboxane B2 release, β-thromboglobulin, and thrombus formation. Cloricromen inhibits LPS (HY-D1056)-induced NF-κB activation, oxidative activity, and TNF-α expression. Cloricromen exhibits protective activity in animal models of shock and peripheral ischaemia. Cloricromen can be used for the research of myocardial ischaemia/reperfusion injury, and ischaemic cerebrovascular disease[1][2][3][4].
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Cloricromen | Cloricromen (Cloricromene) is an orally active platelet inhibitor. Cloricromen inhibits thromboxane B2 release, β-thromboglobulin, and thrombus formation. Cloricromen inhibits LPS (HY-D1056)-induced NF-κB activation, oxidative activity, and TNF-α expression. Cloricromen exhibits protective activity in animal models of shock and peripheral ischaemia. Cloricromen can be used for the research of myocardial ischaemia/reperfusion injury, and ischaemic cerebrovascular disease. | |||||||||||||||||||||
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References
- [1]. Orefice G, et al. No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease. J Int Med Res. 1994 Sep-Oct;22(5):287-91. [Content Brief]
- [2]. Lidbury PS, et al. Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity. Br J Pharmacol. 1993 Sep;110(1):275-80. [Content Brief]
- [3]. Corsini E, et al. Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level. Eur J Pharmacol. 2001 Apr 27;418(3):231-7. [Content Brief]
- [4]. Milei J, et al. Effects of cloricromene on ischemia-reperfusion myocardial damage in the rabbit. Cardiology. 1992;81(2-3):89-99. [Content Brief]
