683746-68-1
Chemical Structure
JNJ-5207787
- CAS No.: 683746-68-1
- Formula:C32H38N4O2
- Molecular Weight:510.67
IUPAC Name: (E)-N-(1-acetylindolin-6-yl)-3-(3-cyanophenyl)-N-(1-(2-cyclopentylethyl)piperidin-4-yl)acrylamide
InChIKey: DSEJCLDJIFTPPH-FMIVXFBMSA-N
SMILES: N#CC1=CC=CC(/C=C/C(N(C2CCN(CCC3CCCC3)CC2)C4=CC=C(CCN5C(C)=O)C5=C4)=O)=C1
Biological Activity: JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ-5207787 | 98.00% | JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors. | ||||||||||||||||||||
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