684645-54-3
Chemical Structure
EF-1502
- CAS No.: 684645-54-3
- Formula:C22H26N2O2S2
- Molecular Weight:414.58
IUPAC Name: 4-((4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)(methyl)amino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol
InChIKey: CUESOMOCKVRNIW-UHFFFAOYSA-N
SMILES: OC1=NOC2=C1C(CCC2)N(C)CC/C=C(C3=C(C=CS3)C)\C4=C(C=CS4)C
Biological Activity: EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy[1].
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EF-1502 | EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy. | |||||||||||||||||||||
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