68576-88-5
Chemical Structure
Enciprazine dihydrochloride
- CAS No.: 68576-88-5
- Formula:C23H34Cl2N2O6
- Molecular Weight:505.43
IUPAC Name: 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(3,4,5-trimethoxyphenoxy)propan-2-ol hydrochloride
InChIKey: RZPWWIJNWAEUTD-UHFFFAOYSA-N
SMILES: OC(CN1CCN(CC1)C2=C(OC)C=CC=C2)COC3=CC(OC)=C(OC)C(OC)=C3.Cl.Cl
Biological Activity: Enciprazine dihydrochloride is an orally active non-benzodiazepine anxiolytic. Enciprazine dihydrochloride acts as an agonist of 5-HT1A receptor (5-HT1AR) and an antagonist of α1-adrenergic receptor (α1-adrenergic receptor) . Enciprazine dihydrochloride induces drug-related electroencephalogram changes by reducing the average power of δ waves and θ waves, and increasing the average power of α waves and fast β waves. Enciprazine dihydrochloride exhibits anti-aggressive activity, with only weak sedative and ataxic effects. Enciprazine dihydrochloride regulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis. Enciprazine dihydrochloride can be used in research related to anxiety disorders, generalized anxiety syndrome and psychosis[1][2][3].
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Enciprazine dihydrochloride | Enciprazine dihydrochloride is an orally active non-benzodiazepine anxiolytic. Enciprazine dihydrochloride acts as an agonist of 5-HT1A receptor (5-HT1AR) and an antagonist of α1-adrenergic receptor (α1-adrenergic receptor) . Enciprazine dihydrochloride induces drug-related electroencephalogram changes by reducing the average power of δ waves and θ waves, and increasing the average power of α waves and fast β waves. Enciprazine dihydrochloride exhibits anti-aggressive activity, with only weak sedative and ataxic effects. Enciprazine dihydrochloride regulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis. Enciprazine dihydrochloride can be used in research related to anxiety disorders, generalized anxiety syndrome and psychosis. | |||||||||||||||||||||
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References
- [1]. Engel J, et al. Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. J Med Chem. 1990;33(11):2976-2981. [Content Brief]
- [2]. Nickel B, et al. Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology. 1989;28(8):799-803. [Content Brief]
- [3]. Matheson GK, et al. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. 1997;55(2):59-65. [Content Brief]
