685847-78-3
Chemical Structure
PX-478 free base
- CAS No.: 685847-78-3
- Formula:C13H18Cl2N2O3
- Molecular Weight:321.20
IUPAC Name: (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide
InChIKey: GSKQMLGAUOTSKT-LBPRGKRZSA-N
SMILES: ClCC[N+](C1=CC=C(C=C1)C[C@H](N)C(O)=O)([O-])CCCl
Biological Activity: PX-478 free base is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 free base also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 free base induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 free base is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis[1][2][3][4].
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PX-478 free base | PX-478 free base is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 free base also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 free base induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 free base is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis. | |||||||||||||||||||||
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References
- [1]. Koh MY, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Molecular cancer therapeutics. 2008 Jan;7(1):90-100. [Content Brief]
- [2]. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. International journal of cancer. 2008 Nov 15;123(10):2430-7. [Content Brief]
- [3]. Ilegems E, et al. HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes[J]. Science translational medicine, 2022, 14(638): eaba9112.
- [4]. Hu G, et al. Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1α inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages[J]. Biomedicine & Pharmacotherapy, 2023, 161: 114333.
