68676-88-0
Chemical Structure
Trichostatin C
- CAS No.: 68676-88-0
- Formula:C23H32N2O8
- Molecular Weight:464.51
IUPAC Name: (R,2E,4E)-7-(4-(dimethylamino)phenyl)-4,6-dimethyl-7-oxo-N-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hepta-2,4-dienamide
InChIKey: YECWTLGLNDDPGE-PIFXLSLCSA-N
SMILES: O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O
Biological Activity: Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].
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Trichostatin C | Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer. Trichostatin C induces differentation of Friend leukemic cells. Trichostatin C exhibits antifungal activity. | |||||||||||||||||||||
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References
- [1]. Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17(4): 425.
- [2]. Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49(2): 563-565.
- [3]. Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo). 1978 Oct;31(10):939-44. [Content Brief]
