691-81-6
Chemical Structure
H-Gly-D-Ala-OH
- CAS No.: 691-81-6
- Formula:C5H10N2O3
- Molecular Weight:146.15
IUPAC Name: glycyl-D-alanine
InChIKey: VPZXBVLAVMBEQI-GSVOUGTGSA-N
SMILES: N([C@@H](C(O)=O)C)C(CN)=O
Biological Activity: H-Gly-D-Ala-OH is a dipeptide containing D-amino acid. H-Gly-D-Ala-OH can be specifically hydrolyzed by renal dipeptidase, which acts on peptide segments with a D-amino acid at the carboxyl terminus. H-Gly-D-Ala-OH enables highly specific detection of renal dipeptidase activity without interference from other serum or urine aminopeptidases. When used in combination with low-dose Sodium nitrite (HY-N11218), H-Gly-D-Ala-OH inhibits the initial spore growth of Clostridium botulinum in pork homogenate, whereas it has no such effect on its own. H-Gly-D-Ala-OH can be used in research related to chronic renal failure, diabetes mellitus and botulism[1][2].
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H-Gly-D-Ala-OH | H-Gly-D-Ala-OH is a dipeptide containing D-amino acid. H-Gly-D-Ala-OH can be specifically hydrolyzed by renal dipeptidase, which acts on peptide segments with a D-amino acid at the carboxyl terminus. H-Gly-D-Ala-OH enables highly specific detection of renal dipeptidase activity without interference from other serum or urine aminopeptidases. When used in combination with low-dose Sodium nitrite (HY-N11218), H-Gly-D-Ala-OH inhibits the initial spore growth of Clostridium botulinum in pork homogenate, whereas it has no such effect on its own. H-Gly-D-Ala-OH can be used in research related to chronic renal failure, diabetes mellitus and botulism. | |||||||||||||||||||||
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References
- [1]. Fukumura Y, et al. Behaviour of urinary dipeptidase in patients with chronic renal failure. Ann Clin Biochem. 1999;36 ( Pt 2):221-225. [Content Brief]
- [2]. Paquet A, Rayman K. Some N-acyl-D-amino acid derivatives having antibotulinal properties. Canadian journal of microbiology. 1987 Jul 1;33(7):577-82.
