691410-93-2
Chemical Structure
α-lipoic acid derivative 1
- CAS No.: 691410-93-2
- Formula:C19H34N2O2S4
- Molecular Weight:450.75
IUPAC Name: N,N'-(propane-1,3-diyl)bis(5-(1,2-dithiolan-3-yl)pentanamide)
InChIKey: QGUXZRFEKWOQQL-UHFFFAOYSA-N
SMILES: O=C(CCCCC1SSCC1)NCCCNC(CCCCC2SSCC2)=O
Biological Activity: α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes[1].
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α-lipoic acid derivative 1 | α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes. | |||||||||||||||||||||
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