6920-31-6
6920-31-6
Chemical Structure
Isobutyryl-L-carnitine chloride
- CAS No.: 6920-31-6
- Formula:C11H22ClNO4
- Molecular Weight:267.75
IUPAC Name: (R)-3-carboxy-2-(isobutyryloxy)-N,N,N-trimethylpropan-1-aminium chloride
InChIKey: FWUACOYFRJEMMP-SBSPUUFOSA-N
SMILES: O=C(C(C)C)O[C@H](CC(O)=O)C[N+](C)(C)C.[Cl-]
Biological Activity: Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isobutyryl-L-carnitine chloride | 98.0% | Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma. | ||||||||||||||||||||
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Isobutyryl-L-carnitine chloride (Standard) | ≥98% | Isobutyryl-L-carnitine chloride (Standard) is the analytical standard of Isobutyryl-L-carnitine chloride (HY-113165A). This product is intended for research and analytical applications. Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma. | ||||||||||||||||||||
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Isobutyryl-L-carnitine chloride-d6 | Isobutyryl-L-carnitine chloride-d6 is the d6-labeled Isobutyryl-L-carnitine chloride (HY-113165A). Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma. | |||||||||||||||||||||
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Isobutyryl-L-carnitine-d3 chloride | 99% | Isobutyryl-L-carnitine-d3 chloride is the d3-labeled Isobutyryl-L-carnitine chloride (HY-113165A). Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma. | ||||||||||||||||||||
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References
- [1]. Luo L, et al. A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker. Analytical chemistry. 2020 Jul 21;92(14):9745-9754.
- [2]. Cao C, et al. Metabonomic analysis of toxic action of long-term low-level exposure to acrylamide in rat serum. Human & experimental toxicology. 2018 Dec;37(12):1282-1292. [Content Brief]
- [3]. Oto J, et al. Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study. Journal of proteomics. 2020 Apr 30;218:103723.
