69658-91-9
Chemical Structure
3-N-Nitroso-N-methylaminopyridine
Synonym(s): 3-NMPY
- CAS No.: 69658-91-9
- Formula:C6H7N3O
- Molecular Weight:137.14
IUPAC Name: N-methyl-N-(pyridin-3-yl)nitrous amide
InChIKey: GOPFSGIKKZFUJK-UHFFFAOYSA-N
SMILES: O=NN(C=1C=NC=CC1)C
Biological Activity: 3-N-Nitroso-N-methylaminopyridine is a non-carcinogenic, non-mutagenic arylalkyl nitrosamine isomer that serves as a substrate for enzymatic metabolic processes. 3-N-Nitroso-N-methylaminopyridine undergoes enzymatic denitrosation, enzymatic N-oxide formation, and limited oxidative demethylation to produce trace amounts of 3-hydroxypyridine. 3-N-Nitroso-N-methylaminopyridine directly induces gene mutations in E. coli, but its mutagenic potential is eliminated by the rodent liver S-100 fraction. 3-N-Nitroso-N-methylaminopyridine shows no carcinogenicity in rats and no mutagenicity in the Ames test. 3-NMPY can be used in studies related to the metabolism and carcinogenic mechanisms of nitrosamine compounds in vitro and in vivo[1][2][3].
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3-N-Nitroso-N-methylaminopyridine | 3-N-Nitroso-N-methylaminopyridine is a non-carcinogenic, non-mutagenic arylalkyl nitrosamine isomer that serves as a substrate for enzymatic metabolic processes. 3-N-Nitroso-N-methylaminopyridine undergoes enzymatic denitrosation, enzymatic N-oxide formation, and limited oxidative demethylation to produce trace amounts of 3-hydroxypyridine. 3-N-Nitroso-N-methylaminopyridine directly induces gene mutations in E. coli, but its mutagenic potential is eliminated by the rodent liver S-100 fraction. 3-N-Nitroso-N-methylaminopyridine shows no carcinogenicity in rats and no mutagenicity in the Ames test. 3-NMPY can be used in studies related to the metabolism and carcinogenic mechanisms of nitrosamine compounds in vitro and in vivo. | |||||||||||||||||||||
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References
- [1]. Heydt G, et al. Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. I. Investigations in vitro. Carcinogenesis. 1982;3(4):445-8.
- [2]. Kerklaan P, et al. Mutagenic activity of three isomeric N-nitroso-N-methylaminopyridines towards Escherichia coli K-12 in in vitro and animal-mediated assays. Carcinogenesis. 1982;3(4):415-21.
- [3]. Preussmann R, et al. Carcinogenicity and mutagenicity testing of three isomeric N-nitroso-N-methylaminopyridines in rats. Journal of the National Cancer Institute. 1979 Jan;62(1):153-6.
