69819-42-7
69819-42-7
Chemical Structure
NTZ-24
- CAS No.: 69819-42-7
- Formula:C10H5Cl2N3O3S
- Molecular Weight:318.14
InChIKey: AVCUCBRQWKTIQP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2
Biological Activity: NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer[1].
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NTZ-24 | NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer. | |||||||||||||||||||||
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