700870-56-0
700870-56-0
Chemical Structure
Methyl gerfelin
- CAS No.: 700870-56-0
- Formula:C16H16O6
- Molecular Weight:304.29
IUPAC Name: methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
InChIKey: BLXSEOJIXHWXQJ-UHFFFAOYSA-N
SMILES: O=C(OC)C1=C(C)C=C(OC2=CC(C)=CC(O)=C2O)C=C1O
Biological Activity: Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methyl gerfelin | 99.9% | Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class. | ||||||||||||||||||||
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References
- [1]. Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. [Content Brief]
- [2]. Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625. [Content Brief]
