70384-91-7
70384-91-7
Chemical Structure
Lortalamine
Synonym(s): LM 1404
- CAS No.: 70384-91-7
- Formula:C15H17ClN2O2
- Molecular Weight:292.76
IUPAC Name: (4aR,10R,10aS)-8-chloro-2-methyl-1,2,3,4,10,10a-hexahydro-4a,10-(epiminoethano)chromeno[3,2-c]pyridin-12-one
InChIKey: MJRPHRMGEKCADU-JVLSTEMRSA-N
SMILES: O=C1N[C@@]23[C@@](CN(CC3)C)([H])[C@](C1)([H])C4=CC(Cl)=CC=C4O2
Biological Activity: Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake[1][2].
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Lortalamine | Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake. | |||||||||||||||||||||
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References
- [1]. Lin KS, et al. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons. Bioorg Med Chem. 2005 Aug 1;13(15):4658-66. [Content Brief]
- [2]. Depin JC, et al. Pharmacology of lortalamine, a new potent non-tricyclic antidepressant. Arzneimittelforschung. 1985;35(11):1655-62. [Content Brief]
