708275-58-5
708275-58-5
Chemical Structure
JNJ-10397049
- CAS No.: 708275-58-5
- Formula:C19H20Br2N2O3
- Molecular Weight:484.18
IUPAC Name: 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea
InChIKey: RBKIJGLHFFQHBE-IRXDYDNUSA-N
SMILES: BrC1=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C=CC(Br)=C1
Biological Activity: JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R[1][2].
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JNJ-10397049 | 99.19% | JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R. | ||||||||||||||||||||
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JNJ-10397049 (Standard) | ≥98% | JNJ-10397049 (Standard) is the analytical standard of JNJ-10397049 (HY-10896). This product is intended for research and analytical applications. JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R. | ||||||||||||||||||||
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References
- [1]. Laura C McAtee, et al. Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4225-9. [Content Brief]
- [2]. Christine Dugovic, et al. Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther. 2009 Jul;330(1):142-51. [Content Brief]
