712313-35-4
712313-35-4
Chemical Structure
(Rac)-HAMI 3379
- CAS No.: 712313-35-4
- Formula:C34H45NO8
- Molecular Weight:595.72
IUPAC Name: 3-((3-carboxycyclohexyl)carbamoyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid
InChIKey: HRJWSEPIRZRGCL-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(OCCCC2=CC=C(OCCCCOC3CCCCC3)C=C2)C(C(NC4CC(C(O)=O)CCC4)=O)=C1
Biological Activity: (Rac)-HAMI 3379 is the racemate of HAMI 3379. HAMI 3379 is a potent and selective Cysteinyl leukotriene (CysLT2) receptor antagonist[1][2].
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(Rac)-HAMI 3379 | (Rac)-HAMI 3379 is the racemate of HAMI 3379. HAMI 3379 is a potent and selective Cysteinyl leukotriene (CysLT2) receptor antagonist. | |||||||||||||||||||||
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References
- [1]. Wunder F, et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010 May;160(2):399-409. [Content Brief]
- [2]. Zhang XY, et al. HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation. J Pharmacol Exp Ther. 2013 Aug;346(2):328-41. [Content Brief]
