713099-37-7
713099-37-7
Chemical Structure
DC_M5_2
- CAS No.: 713099-37-7
- Formula:C22H22BrNO5
- Molecular Weight:460.32
InChIKey: FILGLJILLSAIJW-UHFFFAOYSA-N
SMILES: O=C(COC1=CC=C(C=C1C2C3=C(N(C)C4=C2C(CCC4)=O)CCCC3=O)Br)O
Biological Activity: DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC50 of 9.63 μM and a KD of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction[2]. DC_M5_2 can be used in leukemia-related research[1][2].
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DC_M5_2 | DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC50 of 9.63 μM and a KD of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction. DC_M5_2 can be used in leukemia-related research. | |||||||||||||||||||||
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References
- [1]. Gurung R, et al. Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders. Cancers (Basel). 2023;15(15):3910. Published 2023 Aug 1. [Content Brief]
- [2]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019;29(4):638-645. [Content Brief]
