71395-14-7
71395-14-7
Chemical Structure
Tocainide hydrochloride
- CAS No.: 71395-14-7
- Formula:C11H17ClN2O
- Molecular Weight:228.72
IUPAC Name: 2-amino-N-(2,6-dimethylphenyl)propanamide hydrochloride
InChIKey: AMZACPWEJDQXGW-UHFFFAOYSA-N
SMILES: CC(N)C(NC1=C(C)C=CC=C1C)=O.[H]Cl
Biological Activity: Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].
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Tocainide hydrochloride | 98.63% | Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus. | ||||||||||||||||||||
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References
- [1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [Content Brief]
- [2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45. [Content Brief]
